Our Formula
Citrus bergamot
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Citrus bergamot, a citrus fruit native to Calabria, Italy, has garnered attention for its potential benefits in supporting cardiovascular health. Citrus bergamot is rich in antioxidants, which combat oxidative stress and protect the cardiovascular system from damage caused by free radicals.Citrus bergamot is known to positively affect lipid levels by lowering LDL (bad) cholesterol and increasing HDL (good) cholesterol.
- Cappello, A. R., et al. "Bergamot (Citrus bergamia Risso) flavonoids and their potential benefits in human hyperlipidemia and atherosclerosis: an overview." Mini reviews in medicinal chemistry 16.8 (2016): 619-629.
https://www.ingentaconnect.com/content/ben/mrmc/2016/00000016/00000008/art00004
- Nauman, Mirielle C., and Jeremy J. Johnson. "Clinical application of bergamot (Citrus bergamia) for reducing high cholesterol and cardiovascular disease markers." Integrative food, nutrition and metabolism 6.2 (2019).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497409/
IP-6
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IP-6 is a form of inositol, a type of sugar alcohol that plays a role in cellular processes. Specifically, IP-6 is the phosphorylated form of inositol, meaning it has six phosphate groups attached to it. IP-6 has been observed to slow cardiovascular calcifications, it has also been thoroughly researched for its anti-cancer properties.
IP-6 may bind to iron in the gut and prevent its absorption in the digestive tract, leading to a reduction in iron stores in the body; this can be beneficial for bodybuilders who deal with blood thickness issues.
-"Iron absorption and the iron binding and anti‐oxidant properties of phytic acid." International journal of food science & technology 37.7 (2002): 741-748.
https://ifst.onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2621.2002.00619.x
-”Slowing progression of cardiovascular calcification with SNF472 (IP-6) in patients on hemodialysis: Results of a randomized phase 2b study.” Circulation 2020, 141, 728–739.
-”Gu, M.; Raina, K.; Agarwal, C.; Agarwal, R. Inositol hexaphosphate downregulates both constitutive and ligand-induced mitogenic and cell survival signaling, and causes caspase-mediated apoptotic death of human prostate carcinoma PC-3 cells”. Mol. Carcinog. 2010, 49, 1–12.
Astragalus root
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- Astragalus root has traditionally been used in Chinese medicine for its potential health benefits. Virtually the only dietary supplement that research shows can improve your Kidney health. Atragalus also supports a healthy blood pressure and cardiovascular system.
- "Astragalus (a traditional Chinese medicine) for treating chronic kidney disease." Cochrane Database of Systematic Reviews 10 (2014).
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD008369.pub2/pdf/full
- "Add-on astragalus in type 2 diabetes and chronic kidney disease: A multi-center, assessor-blind, randomized controlled trial." Phytomedicine 130 (2024): 155457.
https://www.sciencedirect.com/science/article/abs/pii/S0944711324001211
Hawthorne berry
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Hawthorn berry, derived from the Crataegus species of plants, has been used in traditional medicine for centuries, particularly for cardiovascular health. may work by dilating blood vessels and improving blood flow. Hawthorn may contribute to lower cholesterol levels, which is beneficial for overall heart health.
- "Hawthorne and the Heart: Modern Research on a Medicinal Tree." Townsend Letter 442 (2020): 92-95.
- "Hawthorn (Crataegus spp.) in the treatment of cardiovascular disease." Pharmacognosy reviews 4.7 (2010): 32.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249900/
Ubiquinol
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Ubiquinol is the active, reduced form of coenzyme Q10 (CoQ10), a substance that's essential for energy production in cells. It's a powerful antioxidant that helps protect cells from oxidative damage. Some studies suggest that ubiquinol may support cognitive function and protect the brain from age-related decline.
Ubiquinol is proposed to support a healthy blood pressure through its effects on endotheial cells in blood vessels.
- "The use of coenzyme Q10 in cardiovascular diseases." Antioxidants 10.5 (2021): 755. https://www.mdpi.com/2076-3921/10/5/755
- Ubiquinol improves endothelial function in patients with heart failure with reduced ejection fraction: a single-center, randomized double-blind placebo-controlled crossover pilot study." American Journal of Cardiovascular Drugs 20 (2020): 363-372.
https://link.springer.com/article/10.1007/s40256-019-00384-y